Article

Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

2020-03-20

Abstract excerpt

Zone I and zone III hepatocytes metabolize ammonia through urea cycle and drug by cytochrome P450, respectively. Ammonia has a cytotoxic effect, and can therefore be used as a selection agent for enrichment of hepatocytes. Besides, isolated hepatocytes from livers can be propagated ex vivo under appropriate condition. However, it has not been investigated so far whether ammonia-treated hepatocyte-like cells are ab...

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Literature Corpus work: b9071014-655a-597d-829b-ad6c2b24d6bd
DOI: 10.1101/2020.03.20.999680

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