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BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma

17 May 2025

Abstract excerpt

BACKGROUND: ccRCC (clear cell renal cell carcinoma) is characterized by metabolic reprogramming and immunosuppression, leading to poor clinical prognosis. In recent years, ammonia-related cell death has attracted increasing attention as a novel mechanism related to tumor progression, but its role in ccRCC has not been clarified. METHODS: In this study, the Ammonia-related Signature (AS) of ccRCC was constructed...

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PMID: 40382614
DOI: 10.1186/s40246-025-00764-3

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