Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

doi:10.1038/ncomms9760

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Article

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

Nature communications - 4 Nov 2015

Murtaza Muhammed, Dawson Sarah-Jane, Pogrebniak Katherine, Rueda Oscar M, Provenzano Elena, Grant John, Chin Suet-Feung, Tsui Dana W Y, Marass Francesco, Gale Davina, Ali H Raza, Shah Pankti, Contente-Cuomo Tania, Farahani Hossein, Shumansky Karey, Kingsbury Zoya, Humphray Sean, Bentley David, Shah Sohrab P, Wallis Matthew, Rosenfeld Nitzan, Caldas Carlos

Abstract excerpt

Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ER-positive and HER2-positive breast cancer receiving two lines of targeted therapy over 3 years. We characterize genomic architecture and infer clonal evolution in eight tumour biopsies and...

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PMID: 26530965
DOI: 10.1038/ncomms9760
PMCID: PMC4659935

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