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Article

Patterns of genomic evolution in advanced melanoma.

Nature communications - 10 Jul 2018

Birkeland E, Zhang S, Poduval D, Geisler J, Nakken S, Vodak D, Meza-Zepeda L A, Hovig E, Myklebost O, Knappskog S, Lønning P E

Abstract excerpt

Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with whole-exome sequencing (WES), we show a low branch to trunk mutation ratio and little intermetastatic heterogeneity, with driver mutations almost completely shared between lesions. Branch...

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Identifiers

PMID: 29991680
DOI: 10.1038/s41467-018-05063-1
PMCID: PMC6039447

Genes

BRAF

Provenance

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