Article
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.
Nature communications - 4 Mar 2021
Vergara Ismael A, Mintoff Christopher P, Sandhu Shahneen, McIntosh Lachlan, Young Richard J, Wong Stephen Q, Colebatch Andrew, Cameron Daniel L, Kwon Julia Lai, Wolfe Rory, Peng Angela, Ellul Jason, Dou Xuelin, Fedele Clare, Boyle Samantha, Arnau Gisela Mir, Raleigh Jeanette, Hatzimihalis Athena, Szeto Pacman, Mooi Jennifer, Widmer Daniel S, Cheng Phil F, Amann Valerie, Dummer Reinhard, Hayward Nicholas, Wilmott James, Scolyer Richard A, Cho Raymond J, Bowtell David, Thorne Heather, Alsop Kathryn, Cordner Stephen, Woodford Noel, Leditschke Jodie, O'Brien Patricia, Dawson Sarah-Jane, McArthur Grant A, Mann Graham J, Levesque Mitchell P, Papenfuss Anthony T, Shackleton Mark
Abstract excerpt
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic changes that characterise lethal metastatic disease is poorly understood. Here, we analyze the evolution of human melanoma progressing from early to late disease in 13 patients by sampling their tumours at multiple sites and times. Whole exome and genome...
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