Article
Molecular and genetic diversity in the metastatic process of melanoma.
The Journal of pathology - 1 May 2014
Harbst Katja, Lauss Martin, Cirenajwis Helena, Winter Christof, Howlin Jillian, Törngren Therese, Kvist Anders, Nodin Björn, Olsson Eleonor, Häkkinen Jari, Jirström Karin, Staaf Johan, Lundgren Lotta, Olsson Håkan, Ingvar Christian, Gruvberger-Saal Sofia K, Saal Lao H, Jönsson Göran
Abstract excerpt
Diversity between metastatic melanoma tumours in individual patients is known; however, the molecular and genetic differences remain unclear. To examine the molecular and genetic differences between metastatic tumours, we performed gene-expression profiling of 63 melanoma tumours obtained from 28 patients (two or three tumours/patient), followed by analysis of their mutational landscape, using targeted deep...
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