Article
Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.
Cancer research - 15 Aug 2016
Harbst Katja, Lauss Martin, Cirenajwis Helena, Isaksson Karolin, Rosengren Frida, Törngren Therese, Kvist Anders, Johansson Maria C, Vallon-Christersson Johan, Baldetorp Bo, Borg Åke, Olsson Håkan, Ingvar Christian, Carneiro Ana, Jönsson Göran
Abstract excerpt
Cancer genome sequencing has shed light on the underlying genetic aberrations that drive tumorigenesis. However, current sequencing-based strategies, which focus on a single tumor biopsy, fail to take into account intratumoral heterogeneity. To address this challenge and elucidate the evolutionary history of melanoma, we performed whole-exome and transcriptome sequencing of 41 multiple melanoma biopsies from...
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