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Article

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.

The Journal of experimental medicine - 16 Mar 2009

Ohnmacht Caspar, Pullner Andrea, King Susan B S, Drexler Ingo, Meier Stefanie, Brocker Thomas, Voehringer David

Abstract excerpt

Lack of immunological tolerance against self-antigens results in autoimmune disorders. During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-reactive T cells that have escaped tolerance induction. However, because DCs can also induce T cell tolerance,...

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Identifiers

PMID: 19237601
DOI: 10.1084/jem.20082394
PMCID: PMC2699126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19237601-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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