Article
Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007
Matthews Kate E, Qin Jim S, Yang Jianping, Hermans Ian F, Palmowski Michael J, Cerundolo Vincenzo, Ronchese Franca
Abstract excerpt
The survival of dendritic cells (DC) in vivo determines the duration of Ag presentation and is critical in determining the strength and magnitude of the resulting T cell response. We used a mouse model to show that Ag-loaded C57BL/6 DC (MHC class II(+/+) (MHC II(+/+))) that reach the lymph node survived longer than Ag-loaded MHC II(-/-) DC, with the numbers of C57BL/6 DC being approximately 2.5-fold the number of...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Survival
- Cells, Cultured
- Dendritic Cells
- Female
- Histocompatibility Antigens Class II
- Immunity, Innate
- Lipopolysaccharides
- Lymph Nodes
- Male
- Mice