Article
Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting function.
Immunology letters - 15 Jan 2006
Walton Kristen L W, He Jianping, Kelsall Brian L, Sartor R Balfour, Fisher Nancy C
Abstract excerpt
Dendritic cells (DC) can direct downstream T-cell responses. Although bacterial adjuvants are strong activators of DC in vitro, the effects of normal enteric bacteria on DC in vivo are not well defined. We used germ-free (GF) mice to determine whether enteric bacteria alter DC phenotype and ability to stimulate naïve T cells. Surface expression of CD11c, CD86, and MHCII was measured on splenic and mesenteric...
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