Article

Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in rats

2022-12-01

Abstract excerpt

<h4>Purpose: </h4> The majority of animal models of Parkinson’s disease (PD) focus on motor symptoms that are induced by unilateral injections of such neurotoxins as 6-hydroxydopamine (6-OHDA) in nigrostriatal dopaminergic pathways. However, motor changes that are induced by unilateral 6-OHDA injections may interfere with the identification of cognitive and affective dysfunction induced by dopaminergic neurodegene...

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Literature Corpus work: 61b0d56e-82fe-50b6-ba74-7133e6955b08
DOI: 10.21203/rs.3.rs-2289492/v1

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