Article

A biophysical framework for accurately identifying antigen single-amino acid escape variants and corresponding variant-specific compensatory TCR sequences

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> The impact of single amino acid substitution on T-cell receptor (TCR) recognition is central to understanding the molecular determinants of TCR specificity and degeneracy during viral mutational escape, cancer recognition, and autoimmunity. In this study, we developed a biophysics-informed computational approach integrating experimental alanine-scan mutagenesis data from the autoimmune-associate...

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Literature Corpus work: 61ace1f9-6f33-5dba-8b22-5b3da96d9048
DOI: 10.64898/2026.02.02.703411

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