Article
Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.
Oncotarget - 9 May 2017
Yang Yuan, Yang Howard H, Hu Ying, Watson Peter H, Liu Huaitian, Geiger Thomas R, Anver Miriam R, Haines Diana C, Martin Philip, Green Jeffrey E, Lee Maxwell P, Hunter Kent W, Wakefield Lalage M
Abstract excerpt
Effective drug development to combat metastatic disease in breast cancer would be aided by the availability of well-characterized preclinical animal models that (a) metastasize with high efficiency, (b) metastasize in a reasonable time-frame, (c) have an intact immune system, and (d) capture some of the heterogeneity of the human disease. To address these issues, we have assembled a panel of twelve mouse mammary...
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