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Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice

7 May 2014

Abstract excerpt

Humanized tumor mice (HTM) were generated by the co-transplantation of human hematopoietic stem cells and human breast cancer cells overexpressing HER2 into neonatal NOD-scid IL2Rγ(null) (NSG) mice. These mice are characterized by the development of a human immune system in combination with human breast cancer growth. Due to concurrent transplantation into newborn mice, transfer of MHC-mismatched tumor cells...

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PMID: 24870377
DOI: 10.4161/mabs.29111

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