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Article

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Structure (London, England : 1993) - 4 Nov 2014

Mari Sara, Ruetalo Natalia, Maspero Elena, Stoffregen Mira C, Pasqualato Sebastiano, Polo Simona, Wiesner Silke

Abstract excerpt

Nedd4-family ubiquitin ligases are key regulators of cell surface receptor signaling. Their dysregulation is associated with several human diseases, including cancer. Under normal conditions, the activity of various Nedd4 E3s is controlled through an autoinhibitory interaction of the N-terminal C2 domain with the C-terminal catalytic HECT domain. Here, we report the structural and functional framework for this...

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Identifiers

PMID: 25438670
DOI: 10.1016/j.str.2014.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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