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Article

The CRL4DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.

The EMBO journal - 15 Nov 2021

Mohamed Weaam I, Schenk Andreas D, Kempf Georg, Cavadini Simone, Basters Anja, Potenza Alessandro, Abdul Rahman Wassim, Rabl Julius, Reichermeier Kurt, Thomä Nicolas H

Abstract excerpt

The cullin-4-based RING-type (CRL4) family of E3 ubiquitin ligases functions together with dedicated substrate receptors. Out of the ˜29 CRL4 substrate receptors reported, the DDB1- and CUL4-associated factor 1 (DCAF1) is essential for cellular survival and growth, and its deregulation has been implicated in tumorigenesis. We carried out biochemical and structural studies to examine the structure and mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-17

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Source

Open in PubMed Open full text

Identifiers

PMID: 34595758
DOI: 10.15252/embj.2021108008
PMCID: PMC8591539

Genes

DCAF1
RBX1
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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