Article

Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement

2025-10-28

Abstract excerpt

<h4>Summary</h4> P97/VCP is a protein unfoldase of the AAA+ ATPase family that plays essential roles in numerous processes, including ER-associated degradation and DNA replication. For unfolding of proteins that are modified with K48-linked ubiquitin chains, p97 works with the heterodimeric cofactor Ufd1-Npl4, and the cofactor Faf1 was shown to enhance this activity during replisome disassembly, yet the mechanism...

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Literature Corpus work: 3164c154-f0fb-5200-a280-6bf40ef3ebdd
DOI: 10.1101/2025.10.27.684972

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