Anaerobic growth of Bacillus subtilis alters the spectrum of spontaneous mutations in the rpoB gene leading to rifampicin resistance.

doi:10.1093/femsle/fnv213

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Article

Anaerobic growth of Bacillus subtilis alters the spectrum of spontaneous mutations in the rpoB gene leading to rifampicin resistance.

FEMS microbiology letters - 1 Dec 2015

Nicholson Wayne L, Park Roy

Abstract excerpt

Spontaneous rifampicin-resistant (RFM(R)) mutants were isolated from Bacillus subtilis 168 cultivated in the presence or absence of oxygen. By DNA sequencing, the mutations were located within Cluster I of the rpoB gene encoding the β subunit of RNA polymerase. The spectrum of RFM(R) rpoB mutations isolated from B. subtilis cells grown anaerobically differed from aerobically grown cells, not only with respect to...

Topics

Anaerobiosis
Anti-Bacterial Agents
Bacillus subtilis
Bacterial Proteins
Base Sequence
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Genetic Fitness
Mutation
Oxygen
Rifampin

Source

Open in PubMed

Identifiers

PMID: 26538577
DOI: 10.1093/femsle/fnv213

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