The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the most common primary brain cancer. It causes death mainly by local invasion via several routes, including infiltration of white matter tracts and penetration of perivascular spaces. However, the pathways that mediate these invasion routes are only partly known. Here, we conduct an integrative study to identify cell states and central drivers of route-specific in...

Topics

Open a Topic to create a Post that cites this publication.

• Biomarkers, Tumor
• Brain Neoplasms
• Cell Image Analysis Techniques
• Epithelial-Mesenchymal Transition
• Gene Expression Regulation, Neoplastic
• Glioblastoma
• Glioma Diagnosis and Treatment
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

e7adf2ea-bead-5b6d-8932-367e837871a9

DOI

10.21203/rs.3.rs-4466481/v1