Article

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

2024-04-25

Abstract excerpt

Glioblastoma (GBM), the most common brain cancer in adults, is characterized by rapid local invasion, along diverse routes such as infiltration of white matter tracts and penetration of perivascular spaces. We investigate the hypothesis that GBM invasion routes correlate with the transcriptional states of individual cells and identify route-specific master regulator genes. Utilizing patient-derived GBM xenograft m...

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Literature Corpus work: 70e34e2a-51b5-591e-b959-47b65b8e0317
DOI: 10.1101/2024.04.23.589925

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