Article
Paralog dependency indirectly affects the robustness of human cells
2019-02-18
Abstract excerpt
<h4>Summary</h4> Gene duplicates provide protection against loss-of-function mutations. This protective redundancy partly relies on the fact that paralogs carry their functions independently, i.e. the inactivation of one gene copy does not impair the function of the other copy. However, a significant fraction of paralogous proteins may form functionally dependent pairs, for instance through heteromerization. As a...
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Identifiers and source
- Literature Corpus work
- 60ff42b3-d180-56f4-8b7b-a67c81ee7736
- DOI
- 10.1101/552208