Article
Evolution: Paralog interference stabilizes gene duplicates.
Current biology : CB - 23 Mar 2026
Swamy Krishna B S, Leu Jun-Yi
Abstract excerpt
Gene duplicates are traditionally viewed as evolutionarily unstable, as one copy can freely accumulate deleterious mutations and be lost. A new study reveals that paralog interference exposes certain mutations to purifying selection, prolonging the survival of duplicates and increasing their chances of functional divergence and long-term retention in the genome.
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