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Article

Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.

Molecular systems biology - 1 Jan 2007

Ihmels Jan, Collins Sean R, Schuldiner Maya, Krogan Nevan J, Weissman Jonathan S

Abstract excerpt

Many genes can be deleted with little phenotypic consequences. By what mechanism and to what extent the presence of duplicate genes in the genome contributes to this robustness against deletions has been the subject of considerable interest. Here, we exploit the availability of high-density genetic interaction maps to provide direct support for the role of backup compensation, where functionally overlapping...

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Identifiers

PMID: 17389874
DOI: 10.1038/msb4100127
PMCID: PMC1847942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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