Article

Global analysis of suppressor mutations that rescue human genetic defects

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. To capture existing knowledge on suppression relationships between human genes, we examined 2,400 published papers for potential interactions identified through either genetic modification of cultured human cells...

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Literature Corpus work: b174f590-a968-5bbc-8d87-77a2ee8b0efc
DOI: 10.1101/2022.11.09.515781

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