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Article

Role of duplicate genes in robustness against deleterious human mutations.

PLoS genetics - 14 Mar 2008

Hsiao Tzu-Lin, Vitkup Dennis

Abstract excerpt

It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5]. In this paper we investigate in detail the contribution of gene duplicates to back-up against deleterious human mutations. Our analysis demonstrates that the...

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Identifiers

PMID: 18369440
DOI: 10.1371/journal.pgen.1000014
PMCID: PMC2265532

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