Article

Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen

2024-06-03

Abstract excerpt

1 Bacterial pathogens that are successful in hospital environments must survive times of intense antibiotic exposure and times of no antibiotic exposure. When these organisms are closely associated with human hosts, they must also transmit from one patient to another for the resistance to spread. The resulting evolutionary dynamics have, in some settings, led to rising levels of resistance in hospitals. Here, we f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60ca21ab-8d1d-5621-8770-eaf22c559a24
DOI: 10.1101/2024.06.03.597162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reversion to sensitivity explains limited transmission of resistance in a hospital pathogenDOI 10.1101/2024.06.03.597162Read

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patientSemantic proximity Read

Rising daptomycin resistance in <i>Enterococcus faecium</i> across a hospital system occurred via rampant recurrent evolution and occasional transmission between patientsSemantic proximity Read

Cryptic Evolution of Heteroresistance as Adaptation to Treatment InterruptionsSemantic proximity Read

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance.Semantic proximity Read

Antibiotic resistance in the absence of selective pressure.Semantic proximity Read

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens.Semantic proximity Read

Antimicrobial treatment impacts resistance in off-target populations of a nosocomial bacterial pathogen: a case-control studySemantic proximity Read

Evolution of Antibiotic Resistance without Antibiotic Exposure.Semantic proximity Read

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of HeteroresistanceSemantic proximity Read

Phenotype and genotype alteration during adaptive evolution of Enterococcus faecalis to antimicrobials.Semantic proximity Read

Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.Semantic proximity Read

The essential role of hypermutation in rapid adaptation to antibiotic stressSemantic proximity Read