Article
Antibiotic resistance in the absence of selective pressure.
International journal of antimicrobial agents - 1 Mar 2001
Gillespie S H
Abstract excerpt
Antibiotic resistance poses a serious threat to modern medical practice making treatment more difficult and is associated with increased mortality among patients infected with resistant organisms. There is clear evidence that acquisition of resistance is associated with a decrease in the fitness of the organisms at least in the short term. Evidence from in vitro experiments indicates that bacteria have the...
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