Article

AcornHRD: an HRD algorithm which was highly associated with anthracycline-based neoadjuvant chemotherapy in Chinese breast cancer

2022-06-27

Abstract excerpt

<h4>Background: </h4> Homologous recombination deficiency (HRD) can result from BRCA dysfunction and is associated with platinum sensitivity, PARP inhibitor, and other DNA-damaging drugs. There are many commercial HRD detection assays, but there is still no uniform standard in China. This study aimed to develop and validate an HRD scoring algorithm. Methods Ninety-six in-house BC samples and 6 HRD positive standa...

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Literature Corpus work: 60c43474-3414-57ad-92c3-d4e133fbec67
DOI: 10.21203/rs.3.rs-1770144/v1

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