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Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology

16 May 2023

Abstract excerpt

Abstract Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose polymerase (PARP) inhibitors as well as the platinum chemotherapy drugs applied to HRD patients. However, it remains a challenge to predict HRD status precisely and economically. Copy number...

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PMID: 37193789
DOI: 10.1038/s42003-023-04901-3

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