Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data.

Molecular oncology - 1 Dec 2025

Zhu Rong, Eason Katherine, Chin Suet-Feung, Edwards Paul A W, Manzano Garcia Raquel, Moulange Richard, Pan Jia Wern, Teo Soo Hwang, Mukherjee Sach, Callari Maurizio, Caldas Carlos, Sammut Stephen-John, Rueda Oscar M

Abstract excerpt

Homologous recombination deficiency (HRD) leads to genomic instability, and patients with HRD can benefit from HRD-targeting therapies. Previous studies have primarily focused on identifying HRD biomarkers using data from a single technology. Here we integrated features from different genomic data types, including total copy number (CN), allele-specific copy number (ASCN) and single nucleotide variants (SNV)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genomics

Share to Homologous Recombination

Share to Mutation

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40260608
DOI: 10.1002/1878-0261.70041
PMCID: PMC12688163

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data.PMID 40260608Read ↗

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.Semantic proximity Read ↗

Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell LinesSemantic proximity Read ↗

Validation of Genomic and Transcriptomic Models of Homologous Recombination Deficiency in a Real-World Pan-Cancer CohortSemantic proximity Read ↗

Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biologySemantic proximity Read ↗

AcornHRD: an HRD algorithm highly associated with anthracycline-based neoadjuvant chemotherapy in breast cancer in ChinaSemantic proximity Read ↗

Pan-cancer Analysis of Homologous Recombination Deficiency in Cell LinesSemantic proximity Read ↗

Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancerSemantic proximity Read ↗

Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohortSemantic proximity Read ↗

AcornHRD: an HRD algorithm highly associated with anthracycline-based neoadjuvant chemotherapy in breast cancer in China.Semantic proximity Read ↗

HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data.Semantic proximity Read ↗

Detecting HRD in whole-genome and whole-exome sequenced breast and ovarian cancersSemantic proximity Read ↗

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.