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Article

AcornHRD: an HRD algorithm highly associated with anthracycline-based neoadjuvant chemotherapy in breast cancer in China.

European journal of medical research - 16 Jul 2024

Pan Jia-Ni, Li Pu-Chun, Wang Meng, Li Ming-Wei, Ding Xiao-Wen, Zhou Tao, Wang Hui-Na, Wang Yun-Kai, Chen Li-Bin, Wang Rong, Ye Wei-Wu, Wu Wei-Zhu, Lou Feng, Wang Xiao-Jia, Cao Wen-Ming

Abstract excerpt

PURPOSE: Our study aimed to develop and validate a homologous recombination deficiency (HRD) scoring algorithm in the Chinese breast cancer population. METHODS AND MATERIALS: Ninety-six in-house breast cancer (BC) samples and 6 HRD-positive standard cells were analyzed by whole-genome sequencing (WGS). Besides, 122 BCs from the TCGA database were down-sampled to ~ 1X WGS. We constructed an algorithm named...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39014466
DOI: 10.1186/s40001-024-01936-y
PMCID: PMC11253386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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