Article

COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export

2023-04-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Neointimal hyperplasia (NH) is a common pathological response to vascular injury and mediated primarily by vascular smooth muscle cell (VSMC) migration and proliferation. The COP9 signalosome (CSN) is formed by 8 canonical subunits (CSN1 through CSN8) with its deneddylation activity residing in CSN5. Each or some of CSN subunits may have deneddylation-independent function. D...

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Literature Corpus work: 609a17ac-ca6f-51c8-b74b-243af8a60246
DOI: 10.1101/2023.04.11.536468

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