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Article

Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.

Cardiovascular research - 28 Apr 2026

Giri Samiksha, Suo Chao, Pardi Ruggero, Fishbein Gregory A, Rezvani Khosrow, Chen Yabing, Cui Taixing, Wang Xuejun

Abstract excerpt

AIMS: Vascular smooth muscle cell (VSMC) phenotypic remodelling is pivotal to neointimal hyperplasia (NH), a common pathological response to vascular injury. COPS5/CSN5/JAB1 harbours the deneddylase of the COP9 signalosome (CSN) holocomplex but also has deneddylation-independent function. The role of COPS5 in VSMCs remains obscure. METHODS AND RESULTS: COPS5/CSN5 was increased in human idiopathic pulmonary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclin-Dependent Kinase Inhibitor p27

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Source

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Identifiers

PMID: 41861053
DOI: 10.1093/cvr/cvag067
PMCID: PMC13123672

Genes

COPS5
COPS8
TP53
CDKN1B
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.PMID 41861053Read ↗

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