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Mammalian COP9 signalosome

22 Oct 2009

Abstract excerpt

The COP9 signalosome (CSN) complex is highly conserved from yeast to human. Although the plant CSN was first identified as a negative regulator of photomorphogenesis, the mammalian CSN is linked to different biological responses such as checkpoint control, signal transduction, development and the cell cycle. Frequent over-expression of the CSN subunit in a variety of human cancers suggests its involvement in cell...

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PMID: 19849719
DOI: 10.1111/j.1365-2443.2009.01349.x

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