Article
The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.
Histology and histopathology - 1 Jun 2010
Zuo Guo-Wei, Kohls Christopher D, He Bai-Cheng, Chen Liang, Zhang Wenli, Shi Qiong, Zhang Bing-Qiang, Kang Quan, Luo Jinyong, Luo Xiaoji, Wagner Eric R, Kim Stephanie H, Restegar Farbod, Haydon Rex C, Deng Zhong-Liang, Luu Hue H, He Tong-Chuan, Luo Qing
Abstract excerpt
The CCN proteins contain six members, namely CCN1 to CCN6, which are small secreted cysteine-rich proteins. The CCN proteins are modular proteins, containing up to four functional domains. Many of the CCN members are induced by growth factors, cytokines, or cellular stress. The CCNs show a wide and highly variable expression pattern in adult and in embryonic tissues. The CCN proteins can integrate and modulate...
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