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Patient-derived xenografts (PDXs) as model systems for human cancer

18 Feb 2020

Abstract excerpt

Patient-derived xenografts (PDXs) are obtained by transplanting fragments of a patient's tumour into immunodeficient mice. Growth and propagation of PDXs allows correlating therapeutic response in vivo with extensive, multi-dimensional molecular annotation, leading to identification of predictive biomarkers. PDXs are increasingly recognised as clinically relevant models of cancer for several reasons, of which the...

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PMID: 32070860
DOI: 10.1016/j.copbio.2020.01.003

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