Article

PTP1B phosphatase puts a brake on iPSC-derived neutrophil motility and antimicrobial function

2023-06-07

Abstract excerpt

Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Neutropenic patients are at high risk for fungal and bacterial infections and can benefit from granulocyte transfusion therapy. Human induced pluripotent stem cells (iPSCs) could provide a robust source of neutrophil-like cells for infusion as they can be generated in large quantities and do not require a donor. Howeve...

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Literature Corpus work: 60484ef6-2b1c-510d-a629-4dce0ab1cefa
DOI: 10.1101/2023.06.05.543775

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