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Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B

15 Jan 2024

Abstract excerpt

Neutrophil-directed motility is necessary for host defense, but its dysregulation can also cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin cytoskeleton and lead to immune dysregulation. Deficiency in ARPC1B, a component of the Arp2/3 complex, results in vascular neutrophilic inflammation; however, the mechanism remains unclear. Here, we generated human induced...

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PMID: 38224139
DOI: 10.1242/jcs.261774

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