Article

Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B

2023-11-17

Abstract excerpt

Neutrophil directed motility is necessary for host defense, but its dysregulation can also cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin cytoskeleton and lead to immune dysregulation. Deficiency in ARPC1B, a component of the ARP2/3 complex, results in vascular neutrophilic inflammation; however, the mechanism remains unclear. Here we generated ARPC1B-deficient human iP...

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Literature Corpus work: ae4d2a67-0e31-5cef-9727-c5ecdfb345e2
DOI: 10.1101/2023.11.16.567429

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