Article

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk

2022-12-09

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVD), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. CHIP was identified using whole exome sequencing data of blood DNA and modeled both as a composite and for common drivers ( DNMT3A , TET2...

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Literature Corpus work: 257c4723-df3e-5711-b8d3-7c4723815e86
DOI: 10.1101/2022.12.08.22283237

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