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Article

Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.

Proteins - 1 Mar 2021

Liu Jenny, Amaral Luis A Nunes, Keten Sinan

Abstract excerpt

Allostery governing two conformational states is one of the proposed mechanisms for catch-bond behavior in adhesive proteins. In FimH, a catch-bond protein expressed by pathogenic bacteria, separation of two domains disrupts inhibition by the pilin domain. Thus, tensile force can induce a conformational change in the lectin domain, from an inactive state to an active state with high affinity. To better understand...

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Identifiers

PMID: 32989832
DOI: 10.1002/prot.26013
PMCID: PMC10623646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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