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Article

Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.

PLoS computational biology - 1 Oct 2011

Dixit Anshuman, Verkhivker Gennady M

Abstract excerpt

The emerging structural information about allosteric kinase complexes and the growing number of allosteric inhibitors call for a systematic strategy to delineate and classify mechanisms of allosteric regulation and long-range communication that control kinase activity. In this work, we have investigated mechanistic aspects of long-range communications in ABL and EGFR kinases based on the results of multiscale...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21998569
DOI: 10.1371/journal.pcbi.1002179
PMCID: PMC3188506

Genes

EGFR

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