Article
ATP allosterically stabilizes integrin-linked kinase for efficient force generation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2022
Martin Isabel M, Nava Michele M, Wickström Sara A, Gräter Frauke
Abstract excerpt
SignificanceThe pseudokinase integrin-linked kinase (ILK) is a central component of focal adhesions, cytoplasmic multiprotein complexes that integrate and transduce biochemical and mechanical signals from the extracellular environment into the cell and vice versa. However, the precise molecular functions, particularly the mechanosensory properties of ILK and the significance of retained adenosine triphosphate...
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