Article

Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization study

2024-07-25

Abstract excerpt

<h4>Background</h4> Lipoprotein(a) (Lp[a]) is a circulating plasma lipoprotein that is emerging as an important independent risk factor for vascular disease. Lp(a) levels are 75-90% heritable, predominantly determined by copy number variation and single nucleotide polymorphisms (SNPs) at the LPA gene. <h4>Methods</h4> Using ∼370K individuals with serum measurements of Lp(a) in the UK Biobank European cohort, w...

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Literature Corpus work: 601a319c-e102-50a2-b64e-dff2d68fe5f6
DOI: 10.1101/2024.07.24.24310950

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