Article
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.
Circulation. Genomic and precision medicine - 1 Aug 2021
Guertin Jakie, Kaiser Yannick, Manikpurage Hasanga, Perrot Nicolas, Bourgeois Raphaëlle, Couture Christian, Wareham Nicholas J, Bossé Yohan, Pibarot Philippe, Stroes Erik S G, Mathieu Patrick, Clavel Marie-Annick, Thériault Sébastien, Boekholdt S Matthijs, Arsenault Benoit J
Abstract excerpt
BACKGROUND: Elevated Lp(a) (Lipoprotein(a)) levels are associated with coronary artery disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS). Studies investigating the association between Lp(a) levels and these diseases in women have yielded inconsistent results. METHODS: To investigate the association of Lp(a) with sex-specific cardiovascular outcomes, we determined the association...
Topics
- Female
- Gene Expression Regulation
- Genetic Loci
- Humans
- Lipoprotein(a)
- Liver
- Male
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide