Genetically Predicted Levels of Lipoprotein(a) and Risk of Cerebrovascular Disease.

doi:10.1161/JAHA.125.045423

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Article

Genetically Predicted Levels of Lipoprotein(a) and Risk of Cerebrovascular Disease.

Journal of the American Heart Association - 3 Feb 2026

Daghlas Iyas, Georgakis Marios K, Arsenault Benoit J, Kim Anthony S, Burgess Stephen, Gill Dipender

Abstract excerpt

BACKGROUND: Lipoprotein(a) (Lp(a)) is a highly atherogenic lipoprotein and the target of investigational therapies. Using a Mendelian randomization study design, we aimed to clarify associations between genetically predicted Lp(a) levels and cerebrovascular disease outcomes and related phenotypes. METHODS: We obtained genetic associations with Lp(a) levels (n=343 681), ischemic stroke subtypes (≤62 100 cases),...

Topics

Humans
Lipoprotein(a)
Risk Factors
Mendelian Randomization Analysis
Phenotype
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Ischemic Stroke
Cerebrovascular Disorders
Risk Assessment
Intracranial Hemorrhages
Female

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Identifiers

PMID: 41608825
DOI: 10.1161/JAHA.125.045423
PMCID: PMC13055462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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