Article
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.
PLoS medicine - 1 Mar 2020
Richardson Tom G, Sanderson Eleanor, Palmer Tom M, Ala-Korpela Mika, Ference Brian A, Davey Smith George, Holmes Michael V
Abstract excerpt
BACKGROUND: Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mendelian randomisation (MR), we sought to compare their causal roles in the aetiology of CHD. METHODS AND FINDINGS: We...
Topics
- Adult
- Aged
- Apolipoprotein A-I
- Apolipoprotein B-100
- Biomarkers
- Cholesterol, HDL
- Cholesterol, LDL
- Coronary Disease
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male