Article
Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry.
Circulation. Genomic and precision medicine - 1 Aug 2021
Satterfield Benjamin A, Dikilitas Ozan, Safarova Maya S, Clarke Shoa L, Tcheandjieu Catherine, Zhu Xiang, Bastarache Lisa, Larson Eric B, Justice Anne E, Shang Ning, Rosenthal Elisabeth A, Shah Amy Sanghavi, Namjou-Khales Bahram, Urbina Elaine M, Wei Wei-Qi, Feng QiPing, Jarvik Gail P, Hebbring Scott J, de Andrade Mariza, Manolio Teri A, Assimes Themistocles L, Kullo Iftikhar J
Abstract excerpt
BACKGROUND: Lp(a) (lipoprotein [a]) levels are higher in individuals of African ancestry (AA) than in individuals of European ancestry (EA). We examined associations of genetically predicted Lp(a) levels with (1) atherosclerotic cardiovascular disease subtypes: coronary heart disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm and (2) nonatherosclerotic cardiovascular...
Topics
- Aged
- Aged, 80 and over
- Black People
- Cardiovascular Diseases
- Female
- Genetic Predisposition to Disease
- Humans
- Lipoprotein(a)