Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.

doi:10.1001/jamacardio.2018.1470

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Article

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.

JAMA cardiology - 1 Jul 2018

Burgess Stephen, Ference Brian A, Staley James R, Freitag Daniel F, Mason Amy M, Nielsen Sune F, Willeit Peter, Young Robin, Surendran Praveen, Karthikeyan Savita, Bolton Thomas R, Peters James E, Kamstrup Pia R, Tybjærg-Hansen Anne, Benn Marianne, Langsted Anne, Schnohr Peter, Vedel-Krogh Signe, Kobylecki Camilla J, Ford Ian, Packard Chris, Trompet Stella, Jukema J Wouter, Sattar Naveed, Di Angelantonio Emanuele, Saleheen Danish, Howson Joanna M M, Nordestgaard Børge G, Butterworth Adam S, Danesh John

Abstract excerpt

Importance: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided any evidence that lowering Lp(a) level reduces CHD risk. Objective: To estimate the magnitude of the change in plasma Lp(a) levels needed to have the same...

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Identifiers

PMID: 29926099
DOI: 10.1001/jamacardio.2018.1470
PMCID: PMC6481553

Genes

LPA
PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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