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Clinical Utility of Lipoprotein(a) and <i>LPA</i> Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease

6 Oct 2020

Abstract excerpt

Importance: Lipoprotein(a) is a highly heritable biomarker independently associated with atherosclerotic cardiovascular disease (ASCVD). It is unclear whether measured lipoprotein(a) or genetic factors associated with lipoprotein(a) can provide comparable or additional prognostic information for primary prevention. Objective: To determine whether a genetic risk score (GRS) comprising 43 variants at the LPA gene,...

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PMID: 33021622
DOI: 10.1001/jamacardio.2020.5398

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